The ratio efficacity/economy of the injected products increases because the first hepatic duct is avoided.

« It seemed convenient to us to raise in the medical literature a consensus which aims at privileging the transcutaneous and intradermal ways because they have the advantage to avoid the first hepatic duct on the contrary to the case of administration per oral way, a great part of the active substance is degraded by an intense metabolism of the hepatocite cells.

The amounts of products injected are reduced by 10 to 20 times

This approach is consolidated by regular plasmatic proportionings which make state of completely satisfactory concentrations and a bio availability suitable when the products are managed by transcutaneous or intradermal way even if the amounts used are 10-20 times lower ». DR RUBIN. 

 Accumulation in the kidneys is reduced

The biodistribution - by intravenous and intradermal ways : the biodistributions of the same molecule are sometimes different: kidneys behaving like compartments of accumulation.

The urinary evacuation is slower

The delay of the urinary excretion by comparison between ways IV and ID ways, the active substance or its metabolites, are in higher quantity in the organism and during a longer time when the product is injected by local way ( J.A.SICARD and A.LICHTWITZ,1929., CHAMBON C., BEAULIEU J.L., CORBEL Da., GUILLOTEAU D).

Conclusion 

Concerning, in particular, the pain of an articulation, at the time of a rheumatism (or a pathological aggression), the pain is mainly due to the local inflammation which is usually treated by anti-inflammatory drugs:

■ By general way: tablets, intramuscular injections.

■ By local way: local injections meadows of the articulation.